Estrolief contains key components and vitamins to aid in hormone metabolism and reduce the risk of hormone-sensitive, abnormal cell proliferation via different mechanisms.
- DIM is the bioactive metabolite of Indole-3-Carbinol (I3C) from cruciferous vegetables. DIM has been shown in studies to better aid in the estrogen metabolism than I3C due to its actions further down the pathway. DIM enhances the estrone conversion to 2-OH-estrone (protective) and decreases the conversion to 4-OH & 16-OH metabolites (persistently estrogenic).
- SDG (Secoisolariciresinol diglucoside) has a strong affinity to the receptor of 4-, 16-OH estrone. It exerts an "amphiteric effect" to reduce the harmful estrogenic effect of 4-OH & 16-OH estrones by occupying the receptors while alleviating menopausal symptoms.
- D-glucarate has been shown to inhibit beta-glucuronidase - an enzyme that recycles toxins and hormone metabolites back into the blood stream rather than excreted and, thus, slows down the detoxification process.
- Formulated with essential coenzymes: 5-MTHF, pyridoxine-5-phosphate, and B12 - to promote the steroids detoxification (ie. methylation, transamination).